Bioinformatics: Principles And Applications

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Bioinformatics: Principles and Applications is a comprehensive text designed to cater to the needs of undergraduate and postgraduate students of biotechnology and bioinformatics. This book will also cater to the requirements of students pursuing short-term diploma as also DOEACC courses in bioinformatics. Beginning with the aim and scope of bioinformatics, the book discusses in detail the essentials of the subject, such as bio-algorithms, bio-databases, molecular viewers, gene annotation methods, molecular phylogeny, and bio-molecular simulations. It further discusses the applications of bioinformatics in protein modeling and computer-aided drug design. The book also presents a discussion on molecular docking, including guidelines for using AutoDock software. The usage of select bioinformatics commercial software modules is also discussed. Written in a lucid style and user-friendly manner, the book with its wide and up to date coverage will be useful to students as well as practising professionals. Key Features Presents a detailed discussion on in silico drug designing and other bio-algorithms such as BLAST and FASTA Discusses applicative and advanced topics such as protein modelling, docking, molecular dynamics, biochemical network, and molecular phylogeny Discusses commercial bioinformatics software modules such as Insight II and GCG Provides a multiple choice question bank at the end of the book to test the understanding of students Includes appendices giving a select list of bio-companies in India, biodatabases with their websites, and a glimpse of the emerging research areas in the subject

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Dr. Zhumur Ghosh is currently a researcher at the Stanford University School of Medicine, California, USA. A PhD from Computational Biology Group of the Indian Association for the Cultivation of Science, Kolkata, she did her Masters in Physics from University of Calcutta and Advanced Diploma in Bioinformatics from the Department of Biophysics, Molecular Biology and Genetics, University of Calcutta. She has also published papers in several national and international journals of repute. Dr. Bibekanand Mallick is a researcher in bioinformatics at Wadsworth Center, New York State Department of Health, New York, USA. He completed his Ph D from Indian Association for the Cultivation of Science (IACS), Kolkata and M. Tech in Biotechnology & Biochemical Engineering from Indian Institute of Technology (IIT) Kharagpur. He has published papers in several international journals of repute.Table of ContentsPreface PART I: Introduction to Bioinformatics A Word on Bioinformatics PART II: Biological Databases Sequence and Molecular File Formats Databases in Bioinformatics – An Introduction Biological Sequence Databases Protein 3D Structure and Classification Databases PART III: Bio-algorithms and Tools Sequence Alignments Gene Prediction Methods: Principles and Challenges Molecular Phylogeny Molecular Viewers PART IV: Protein Modelling and Drug Design Protein Structure and Modelling Bioinformatics in Computer-aided Drug Design PART V: Modelling of Biomolecular Systems Simulation and Statistical Protocols Biochemical Networks PART VI: Bioinformatics Essentials Commercial Bio-software Appendix I: Perspectives of Emerging Research Areas in Bioinformatics ? RNAi, Epigenetics, and Stem Cells Appendix II: Bioinformatics Database Collection with their Websites and Descriptions Appendix III: List of Bioinformatics-related Journals Appendix IV: Bio-companies and Bioinformatics-related Courses Available in India Test Your Understanding Glossary Index