Bioprocess Engineering Principles

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The emergence and refinement of techniques in molecular biology has changed our perceptions of medicine, agriculture and environmental management. Scientific breakthroughs in gene expression, protein engineering and cell fusion are being translated by a strengthening biotechnology industry into revolutionary new products and services. Many a student has been enticed by the promise of biotechnology and the excitement of being near the cutting edge of scientific advancement. However, graduates trained in molecular biology and cell manipulation soon realise that these techniques are only part of the picture. Reaping the full benefits of biotechnology requires manufacturing capability involving the large-scale processing of biological material. Increasingly, biotechnologists are being employed by companies to work in co-operation with chemical engineers to achieve pragmatic commercial goals. For many years aspects of biochemistry and molecular genetics have been included in chemical engineering curricula, yet there has been little attempt until recently to teach aspects of engineering applicable to process design to biotechnologists. This textbook is the first to present the principles of bioprocess engineering in a way that is accessible to biological scientists. Other texts on bioprocess engineering currently available assume that the reader already has engineering training. On the other hand, chemical engineering textbooks do not consider examples from bioprocessing, arm are written almost exclusively with the petroleum and chemical industries in mind. This publication explains process analysis from an engineering point of view, but refers exclusively re the treatment of biological systems. Over 170 problems and worked examples encompass a wide range of applications, including recombinant cells, plant and animal cell cultures, immobilised catalysts a. s well as traditional fermentation systems. Table of Contents Preface Part 1 Introduction Chapter 1 Bioprocess Development: An Interdisciplinary Challenge Chapter 2 Introduction to Engineering Calculations Chapter 3 Presentation and Analysis of Data Part 2 Material and Energy Balances Chapter 4 Material Balances Chapter 5 Energy Balances Chapter 6 Unsteady-State Material and Energy Balances Part 3 Physical Processes Chapter 7 Fluid Flow and Mixing Chapter 8 Heat Transfer Chapter 9 Mass Transfer Chapter 10 Unit Operations Part 4 Reactions and Reactors Chapter 11 Homogeneous Reactions Chapter 12 Heterogeneous Reactions Chapter 13 Reactor Engineering Appendices Appendix A Conversion Factors Appendix B Physical and Chemical Property Data Appendix C Steam Tables Appendix D Mathematical Rules D.1  Logarithms D.2  Differentiation D.3  Integration References Index