Chemical Genomics

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Advances in chemistry, biology, and genomics coupled with laboratory automation and computational technologies have led to the rapid emergence of the multidisciplinary field of chemical genomics. This edited text with contributions from expertsin the field discusses evolving concepts, essential techniques, and a wide range of applications to help further the study of chemical genomics. The beginning chapters provide an overview of the basic principles of chemical biology and chemical genomics. This is followed by a technical section that describes the sources of small molecule chemicals, the basics of high-throughput screening technologies, various bioassays for biochemical-, cellular-, and organism-based screens, and computational approaches. The final chapters connect the chemical genomics field with personalized medicine and the druggable genome for future discovery of new therapeutics. In selected chapters, a resource section is included for further information. This book provides an introduction to the principles of chemical genomics, serves as a resource for the associated technologies, and gives readers general concepts, useful vocabulary, practical techniques, and broad, forward-thinking perspectives. This book will be valuable to researchers, professionals, and students in many fields besides chemical genomics, including biology, biomedicine, chemistry, and drug discovery.

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Haian Fu is a Professor of Pathology, Hematology, and Medical Oncology at Emory University School of Medicine. He also serves as director of the Chemical Biology Discovery Center and co-director of the Discovery and Developmental Therapeutics Program at the Winship Cancer Institute at Emory University. His research focuses on protein-protein interactions in signal transduction pathways that control cell survival and death in normal and cancer cells. He serves on the editorial board of several scientific journals, including Current Chemical Genomics. He edited Protein-Protein Interactions: Methods and Applications (2004). Dr Fu has been recognized by various honors including the PhRMA Faculty Development Award, the Burroughs Wellcome Fund New Investigator Award, the GRA Distinguished Investigator Award and the Georgia Cancer Coalition Distinguished Cancer Scholar. He is also a recipient of the Award for Excellence in Mentorship by the Emory Graduate Division of Biological and Biomedical Sciences (2000) and the Emory Pharmacology Teaching Excellence Award (2006).