Chiral Chromatography

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The separation of chiral compounds is essential in drug synthesis, as normally only one of the mirror images (enantiomers) is active. Regulatory legislation is very tight in this area as the different 'handiness' of a compound can have a great effect on its function. There were a number of books on this subject published in the late eighties but most of these are now out of date if not out of print. This subject is still extremely important in the pharmaceutical industry and there is a demand for newer more up to date books which appears not to have been met by the number of books which have published in recent years. This book will add to these and will complement other titles in the Separation Science Series.

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Thomas E. Beesley Advanced Separation Technologies Inc., Whippany, New Jersey, USA Raymond P.W. Scott Chemistry Department, Georgetown University, Washington DC, USA and Chemistry Department, Birkbeck College, University of London, UK Table of Contents An Introduction to Chiral Chromatography Mechanism of Solute Retention Molecular Interactions The Basic Gas Chromatograph GC Chiral Stationary Phases and Columns Chiral Gas Chromatography Applications The Basic Liquid Chromatograph Liquid Chromatography Chiral Stationary Phases Preparation of LC Chiral Phases and Columns Column Temperature and Mobile Phase Composition: Their Effect on Column Length and Analysis Time Chiral Liquid Chromatography Applications Preparative Chiral Chromatography Chiral Separations by Capillary Electrophoresis and Capillary Electrochomatography An Experimental Approach to Chiral Chromatography Bibliography Appendix Index