Dermatokinetics of Therapeutic Agents

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Novel drug delivery technologies strive to bypass challenging biological layers to elicit desired pharmacological activity. The skin, one of our key defensive barriers, is imperfect, and may allow certain topically applied substances or toxins to pass. The dermatokinetics of a drug determines the efficacy of treatment of skin disorders. Presenting the first comprehensive reference on this important area of research, Dermatokinetics of Therapeutic Agents includes a general overview of the theoretical as well as practical aspects of dermatokinetics and addresses the impact of nature of a drug delivery system on the dermatokinetics of drugs. Chapters and illustrations cover the introductory aspects significance, methods, and models used indermatokinetic studies of therapeutic agents. Topics include: Theoretical Models for Dermatokinetics of Therapeutic AgentsDrug Delivery Approaches to Modulate Dermatokinetics of DrugsConventional Methods of Cutaneous Drug SamplingCutaneous MicrodialysisSampling Substrates by Skin PermeabilizationSpectroscopic Techniques in Dermatokinetics StudiesRegulatory Perspective of Dermatokinetic Studies