Disorders of Hemoglobin: Genetics, Pathophysiology, and Clinical Management

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Disorders of Hemoglobin is the first comprehensive reference on the genetic and acquired disorders of hemoglobin in over a decade. It stands as the definitive work on the genetics, pathophysiology, and clinical management of this wide range of disorders. Drs. Steinberg, Forget, Higgs, and Nagel have gathered the absolute world authorities on the science and clinical management of thalassemias, sickle cell disease, and other inherited and acquired hemoglobinopathies to create this authoritative textbook for researchers and clinicians alike. This text is divided into eight distinct sections, and includes coverage of the molecular and genetic basis of hemoglobinopathies and thalassemias, their epidemiology and genetic selection, and the diagnosis and special treatments of ^D*b and ^D*a thalassemias, sickle cell disease, Hb E, unstable hemoglobins, Hb M disorders, and acquired and secondary disorders of hemoglobin. Clinical featuresof all disorders are anchored to the scientific and pathophysiological events that precede them; providing clinicians with a clear scientific background of the disorders they treat, and scientists with an essential link between their research and its clinical manifestation. Disorders of Hemoglobin is the only single-source reference of its kind for hematologists, internists, pediatricians, clinical investigators, and geneticists worldwide.