Drug Transporters: Molecular Characterization and Role in Drug Disposition

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A comprehensive guide to drug transporters that influence the absorption, distribution, and elimination of drugs in the bodyThe development of powerful expression cloning and genome analysis techniques has facilitated the molecular identification and characterization of numerous transporters that play a crucial role in drug disposition. Explaining the principles of drug transport and the associated techniques, Drug Transporters: Molecular Characterization and Role in Drug Disposition:*Provides a comprehensive overview of drug transporters*Includes specific descriptions of transporter families, including substrate and inhibitor specificity, subcellular and tissue localization, mechanisms governing transport, species differences, the clinical implications of these transporters in human physiology and disease, and their role in drug distribution, elimination, and interactions in drug therapy*Describes transporter-mediated drug disposition, a newly emerging field in drug therapy*Gives a comprehensive summary of drug transport across biological membranes*in the liver, brain, kidney, and intestine*Provides balanced coverage of mechanistic aspects and functional outcomes*Features chapters contributed by distinguished scientists in their specialty areas*Provides sufficient detail to enable non-specialists to understand the principles and techniquesThis authoritative guide is a practical hands-on desk reference for researchers in academia and the pharmaceutical industry and scientists in government agencies. It is also an excellent text for graduate-level courses in the pharmaceutical and pharmacology fields.

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Guofeng You, PhD, is an Associate Professor at the Ernest Mario School of Pharmacy at Rutgers University.Marilyn E. Morris, PhD, is a Professor of Pharmaceutical Sciences in the School of Pharmacy and Pharmaceutical Sciences and Associate Dean in the Graduate School at the University at Buffalo, State University of New York.