Introduction to the Pharmaceutical Sciences: An Integrated approach

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This unique textbook provides an introductory, yet comprehensive overview of the pharmaceutical sciences. It is the first text of its kind to pursue an interdisciplinary approach. Readers are introduced to basic concepts related to the specific disciplines in the pharmaceutical sciences, including pharmacology, pharmaceutics, pharmacokinetics, and medicinal chemistry. In an easy-to-read writing style, the book provides readers with up-to-date information on pharmacogenomics and includes comprehensive coverage of industrial drug development and regulatory approval processes. Each chapter includes critical-thinking exercises, as well as numerous figures, tables, and graphs. Many chapters contain review questions, practice problems, and cases. More than 160 illustrations complement the text. Key Features NEW Case Studies provide students with real-world examples and encourage them to think critically. Detailed illustrations throughout the book help reinforce key principles. Emphasis on chemical, biological, and mathematical principles is balanced to help students gain a broad understanding of modern pharmaceutical science and its applications Review Questions at the end of each chapter help students evaluate their level of comprehension Key Concepts sections provide a quick review of important material. Chapter Outlines, tables, and boxes help students master the material. Additional Reading section points readers to more information. Table of Contents Part I: Drug Chemistry Chapter 1 Introduction Chapter 2 Drugs and Their Targets Chapter 3 Ionization of Drugs Chapter 4 Solubility and Lipophilicity Part II: Drug Delivery Chapter 5 Transport Across Biological Barriers Chapter 6 Drug Absorption Chapter 7 Drug Delivery Systems Part III: Drug Disposition Chapter 8 Drug Distribution Chapter 9 Drug Excretion Chapter 10 Drug Metabolism Chapter 11 Pharmacokinetic Concepts Part IV: Drug Action Chapter 12 Ligands and Receptors Chapter 13 Mechanisms of Drug Action Chapter 14 Dose-Response Relationships Part V: Drug Therapy Chapter 15 Therapeutic Variability Chapter 16 Drug Interactions Chapter 17 Pharmacogenomics Part VI: Special Topics Chapter 18 Biopharmaceutical Drugs Chapter 19 Drug Discovery and Approval Index