Mark's Essentials of Medical Biochemistry: A Clinical Approach

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Based on the Second Edition of Marks' Basic Medical Biochemistry: A Clinical Approach, Marks' Essentials of Medical Biochemistry has been streamlined to focus on only the most essential biochemical concepts important to medical students. The authors present facts and pathways to emphasize how the underlying biochemistry is related to the body's overall physiological functions. This text presents patients to the students as the biochemistry is being discussed, which strengthens the link between biochemistry and medicine and allows the student to learn about this interaction as the biochemistry is presented. Each chapter includes clinical and biochemical notes and comments, questions and answers to encourage further thinking, and suggested references for those who would like to pursue a particular topic in more depth. Table of Contents Fuel metabolism An Overview of Fuel Metabolism Chemical and biological foundations of biochemistry Water, Acids, Bases, and Buffers Structures of the Major Compounds of the Body Amino Acids in Proteins Structure-Function Relationships in Proteins Enzymes as Catalysts Regulation of Enzymes Cell Structure and Signaling by Chemical Messengers Gene expression and protein synthesis Structure of the Nucleic Acids Synthesis of DNA Transcription: Synthesis of RNA Translation: Synthesis of Proteins Regulation of Gene Expression Use of Recombinant DNA Techniques in Medicine Oxidative metabolism and the generation of atp Cellular Bioenergetics: ATP and O2 Tricarboxylic Acid Cycle Oxidative Phosphorylation, Mitochondrial Function, and Oxygen Radicals Generation of ATP from Glucose: Glycolysis Oxidation of Fatty Acids and Ketone Bodies Carbohydrate metabolism Basic Concepts in the Regulation of Fuel Metabolism by Insulin, Glucagons and Other Hormones Digestion, Absorption, and Transport of Carbohydrates Formation and Degradation of Glycogen Pathways of Sugar Metabolism: Pentose Phosphate Pathway, Fructose and Galactose Metabolism Synthesis of Glycosides, Lactose, Glycoproteins, and Glycolipids Gluconeogenesis and Maintenance of Blood Glucose Levels LIpid metabolism Digestion and Transport of Dietary Lipids Synthesis of Fatty Acids, Triacylglycerols, and the Major Membrane Lipids Cholesterol Absorption, Synthesis, Metabolism and Fate Integration of Carbohydrate and Lipid Metabolism Nitrogen metabolism Protein Digestion and Amino Acid Absorption Fate of Amino Acid Nitrogen: Urea Cycle Synthesis and Degradation of Amino Acids Tetrahydrofolate, Vitamin B12, and S-Adenosylmethionine Purine and Pyrimidine Metabolism Intertissue Relationships in the Metabolism of Amino Acids