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Pharmacogenomics: Methods and Protocols 1st Edition 4.0%OFF

Pharmacogenomics: Methods and Protocols 1st Edition

by Federico Innocenti

  • ISBN

    :  

    9781588294401

  • Publisher

    :  

    Humana Press

  • Subject

    :  

    Medical Study & Revision Guides & Reference Material

  • Binding

    :  

    Hardcover

  • Year

    :  

    2005

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14500.0

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13920.0

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  • Description

    Expert researchers and physician/clinicians describe in detail the newest and most commonly used technologies today in this rapidly advancing field. The authors provide readily reproducible methods for assessing the functional consequences of a certain polymorphism, evaluate the variety of genotyping platforms currently available, and discuss the management of pharmacogenomic information. Highlights include techniques for making a snapshot of the allele-specific variation in human gene expression, genome wide analysis of allele-specific expression using oligo microarrays, in vivo assays with HaploChIP, SNP genotyping in DNA pools, and PharmGKB, the pharmacogenetics and pharmacogenomics knowledge base. The methodologies for genotyping include denaturing high-performance liquid chromarography, pyrosequencing, kinetic-fluorescence detection, mass spectrometry, and TaqMan assay for insertion/deletions.

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