Download App
>> | LShop | >> | Book | >> | Medicine | >> | Medicine: General Is... | >> | Pharmacokinetics And... |
ISBN
:
9783527329540
Publisher
:
Wiley-VCH
Subject
:
Medicine: General Issues
Binding
:
HARDCOVER
Pages
:
268
Year
:
2012
₹
13750.0
₹
11825.0
Buy Now
Shipping charges are applicable for books below Rs. 101.0
View DetailsEstimated Shipping Time : 5-7 Business Days
View DetailsDescription
In this new edition of a bestseller, all the contents have been brought upto-date by addressing current standards and best practices in the assessmentand prediction of ADMET properties. Although the previous chapterlayout has been retained, substantial revisions have been made, with newtopics such as pro-drugs, active metabolites and transporters covered indetail in a manner useful to the Drug Discovery scientist. The authorsdiscuss the parameters and processes important for the absorption, distributionand retention of drug compounds in the body, plus the potentialproblems created by their transformation into toxic byproducts. Uniquely comprehensive, the book relates physicochemistry and chemical structureto pharmacokinetic properties and ultimately drug efficacy and safety.While aimed at all those dealing professionally with the developmentand application of pharmaceutical substances, the readily comprehensiblestyle makes this book equally suitablefor students of pharmacy andrelated subjects.
Author Biography
Dennis Smith worked in the pharmaceutical industry for more than 30 years since gaining his PhD from the University of Manchester (UK). He worked at Pfizer Global R D at Sandwich for 24 years, with the role of Vice President for Pharmacokinetics, Dynamics and Metabolism. During his career he directly contributed to the Discovery and Development of eight NCEs. Now retired he is still active in an academic (Visiting Professor, University of Liverpool ) Honary Professor, University of Capetown) andin an advisory capacity. His research interests and publications span all aspects of drug discovery and development, particularly where drug metabolism impacts on the design of more efficacious and safer drugs.Charlotte Allerton obtained her first degree in chemistry from the University of Nottingham, and a MPhil in organic chemistry from the University of Cambridge. She joined the Medicinal Chemistry department in Pfizer at Sandwich in 1993 and worked across a range of disease areas, before joining the Pharmacokinetics, Dynamics and Metabolism (PDM) department in 2007. In 2008 Charlotte Allerton became the PDM Sandwich Site Lead.Amit Kalgutkar received his PhD in organic chemistry from Virginia Polytechnic Institute (USA) and conducted a post-doctoral fellowship at the Department of Biochemistry, Vanderbilt University School of Medicine. He Joined Pfizer in 1999, where he is currently a Research Fellow in the Drug Metabolism Group (Groton Laboratories). He is also an adjunct Professor in the Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island.Han van de Waterbeemd studied physical organic chemistry at the Technical University of Eindhoven and did a PhD in medicinal chemistry at the University of Leiden, The Netherlands. In his pharmaceutical career he worked for Roche, Pfizer and AstraZeneca. His research interests include the role of molecular properties in drug disposition and computational modeling of ADMET properties.Don Walker obtained a degree in biochemistry from the Unviersity of London (UK). He worked for Pfizer for 24 years in the Pharmacokinetics, Dynamics and Metabolism Department contributing scientific leadership to the drug metabolism and pharmacokinetic evaluations on many drug discovery and development projects across a range of therapeutic areas including cardiovascular, allergy and respiratory, anti-infectives and sexual health. Following his retirement in 2010 he has continued to provide occasional consulting and lecturing in the field of metabolism and pharmacokinetics.
Related Items
-
of
Pharmacokinetics : Principles and Applications
Mehdi Boroujerdi
Starts At
12986.0
18291.0
29% OFF
Pharmacokinetics, Second Edition (Drugs and the Pharmaceutical Sciences)
Milo Gibaldi
Starts At
3235.0
3995.0
19% OFF
Pharmacokinetics: Regulatory, Industrial, Academic Perspectives (Drugs and the Pharmaceutical Sciences)
Peter Welling
Starts At
1274.0
1795.0
29% OFF
Medical Imaging 2005: Visualization, Image-Guided Procedures And Display: 13-15 February 2005, San Diego, California, USA (Progress in Biomedical Optics and Imaging)
Robert L.
Starts At
7900.0
10395.0
24% OFF
Enteroviral and Toxin Mediated Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Other Organ Pa
John Richardson
Starts At
1865.0
2555.0
27% OFF
100 Questions & Answers About Parkinson Disease
Abraham Lieberman
Starts At
606.0
819.0
26% OFF
Homecare Management of the Blood Cell Transplant Patient
Cathy H. Kelley
Starts At
1262.0
1706.0
26% OFF