Quaternary Stereocenters: Challenges and Solutions for Organic Synthesis

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The synthesis of quaternary stereocenters in organic chemistry is by far the most challenging task, since very special reaction conditions are necessary to reach the goal, and many unwanted side reactions have to be suppressed. Filling the gap in the literature, this book presents everything there is to know about this topic. By covering the quaternary stereocenters found in a range of important and useful molecules in pharmaceutical and medicinal applications, as well as in thousands of natural products, the title provides the know-how chemists need to synthesize important drugs. The top quality authors come from different scientific backgrounds and thus present a different focus on quaternary stereocenters in synthetic targets. Most of the chapters concentrate on a specific type of reaction or methodology, with the relevant authors chosen for their expertise in this field. The chapters do not aim to cover the topic comprehensively, but rather the authors have compiled examples that reflect their personal choice. All of the chapters include intentionally diastereoselective reactions, in some cases even kinetic resolutions, alongside enantioselective procedures. From the contents: Important Natural Products Important Pharmaceuticals and Intermediates Aldol Reactions Michael Reactions and Conjugate Additions Cycloaddition Reactions Rearrangement Reactions Alkylation of Ketones and Imines Asymmetric Allylic Alkylation Asymmetric Cross Coupling and Heck Reactions Phase Transfer Catalysis Enzymatic Methods Radical Reactions A must for organic chemists in academia, the pharmaceutical industry and medicine.Filling the gap in the literature, this book presents everything there is to know about this topic. By comprehensively covering the quaternary stereocenters found in a range of important and useful molecules in pharmaceutical and medicinal applications, as well as in thousands of natural products, the book provides the know-how chemists need to synthesize challenging molecules with numerous applications. A must for organic chemists in academia, the pharmaceutical industry and medicine. From the Contents: Important Natural Products Important Pharmaceuticals and Intermediates Aldol Reactions Michael Reactions and Conjugate Additions Cycloaddition Reactions Rearrangement Reactions Alkylation of Ketones and Imines Asymmetric Allylic Alkylation Asymmetric Cross Coupling and Heck Reactions Phase Transfer Catalysis Enzymatic Methods Radical Reactions