The Genetics Of Cognitive Neuroscience

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The Genetics of Cognitive Neuro science aims to give the reader a working understanding of the influence of specific genetics variants on cognition, affective regulation, personality, and central nervous system disorders. It has been known that the aspects of behavior runs in families; studies shows that characteristics related to cognition, temperament, and all major psychiatric disorders are heritable. The book offers a primer on understanding the genetic mechanisms of such inherited traits. The chapters emphasize fundamental issues regarding the design of experiments, the use of bioinformatics tools, the integration of data from different levels of analysis and the validity of finding, arguing that association between genes and cognitive processes must be replicable and placed in a neurobiological context for validation. About The Author Terry E. Goldberg is Professor of Psychiatry and Behavioral Sciences at Albert Einstein College of Medicine and Director of Neurocognitive Research at the Zucker Hillside Hospital’s Psychiatry Research Division and the Litwin Zucker Alzheimer’s Research Center at the Long Island Medical Center in Manhasset, New York. Daniel R. Weinberger is Chief of the Clinical Brain Disorders Branch and Director of Genes, Cognition, and Psychosis Program at the National Institute of Mental Health of the National Institutes of Health in Bethesda,Maryland. Table of Contents Preface Introduction I. Methodologies for Genetic Association Studies of Cognition 1 Molecular Genetics and Bioinformatics: An Outline for Neuropsychological Genetics — Lucas Kempf and Daniel R. Weinberger 2 Statistical Methods in Neuropsychiatric Genetics — Kristin K. Nicodemus and Fengyu Zhang 3 Animal Models of Genetic Effects on Cognition — Francesco Papaleo, Daniel R. Weinberger, and Jingshan Chen II Genetic Approaches to Individual Differences in Cognition and Affective Regulation 4 The Genetics of Intelligence Danielle Posthuma — Eco J.C. de Geus, and Ian J- Deary 5 Candidate Genes Associated with Attention and Cognitive Control — John Fossella, Jin Fan, and Michael I. Posner 6 Genetics of Corticolimbic Function and Emotional Reactivity — Ahmad R. Hariri, Erika E. Forbes, and Kristin L. Bigos 7 Genes Associated with Individual Differences in Cognitive Aging — Terry E. Goldberg and Venkata S. Mattay III Genetic Studies of Cognition and Treatment Response in Neuropsychiatric Disease 8 Genetics of Dyslexia: Cognitive Analysis, Candidate Genes, Comorbidities, and Etiologic Interactions — Bruce F. Pennington, Lauren M. McGrath, and Shelley D. Smith 9 Cognitive Intermediate Phenotypes in Schizophrenia Genetics — Gary Donohoe, Terry E. Goldberg, and Aiden Corvin 10 The Genetic Basis for the Cognitive Deterioration of Alzheimer’s Disease — John M. Ringman and Jeffrey L. Cummings 11 Pharmacogenetic Approaches to Neurocognition in Schizophrenia — Katherine E. Burdick and Anil K. Malhotra Contributors Index