The Molecular and Genetic Basis of Neurologic and Psychiatric Disease, 3e

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110 of the world's foremost authorities explore the latest advances in molecular and cellular neurobiology and molecular neurogenetics and their implications for the development of pharmacologic or gene therapy for patients with genetic diseases of the nervous system. The 3rd Edition features a new section on psychiatric diseases, 26 additional new chapters, and an even stronger clinical focus, offering practical guidance on a full range of diseases and the roles that molecular biology and genetics play in their diagnosis and management.the latest advances in molecular research.Includes a brand-new section on Psychiatric Diseases, edited by Dr. Eric J. Nestler, that features chapters on Challenges in Psychiatric Genetics xB7; Depression xB7; Bipolar Disorders xB7; Schizophrenia xB7; Obsessive-Compulsive Disorder and Tourette's Syndrome xB7; Molecular and Genetic Basis of Addiction xB7; and Autism.Offers two new chapters on Degenerative Diseases and Protein Processing and Prion Diseases, authored by Dr. Stanley B. Prusiner, winner of the 1997 Nobel Prize in Medicine for his research defining the molecular and genetic basis of the spongiform encephalopathies and the expression of the prion gene under both physiologic and pathologic conditions.Incorporates new data and insights from the analysis and sequencing of the human genome into three new chapters on The Human Genome Project and Neurological Disease, Gene Therapy, and Ethical Issues in Diagnosis and Therapy.Features 21 additional new chapters: Animal Models (mice, worms, flies) xB7; Gene Targeting/Gene Mapping xB7; Genotype/Phenotype Correlations xB7; Mitochondrial Disorders Due to Mutations in the Nuclear Genome xB7; Mitochondria in Neurodegenerative Disorders xB7; Lysosomal Membrane Disorders - LAMP-2 Deficiency xB7; Alzheimer's Disease and Related Dementias xB7; Movement Disorders xB7; Neuronopathies xB7; Limb Girdle Muscular Dystrophies xB7; Congenital Myopathies xB7; Hereditary Inclusion - Body Myopathies xB7; Facioscapulohumeral Muscular Dystrophy xB7; The Phakomatoses: Disorders of Skin and Brain xB7; Disorder of Galactose Metabolism xB7; Disorders of Glucose Transport xB7; Congenital Disorders of Glycosylation xB7; Disorders of Glutathione Metabolism xB7; Friedreich Ataxia and Iron Metabolism xB7; The Influence of Alpha Tocopherol, Caloric Restriction and Genes on Life Span xB7; and A Neurologic Gene Map.

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Edited by Roger N. Rosenberg, MD, Abe (Brunky), Morris and William Zale Distinguished Chair in Neurology and Professor of Neurology and Physiology, University of Texas Southwestern Medical Center at Dallas; Attending Neurologist, Zale-Lipshy University Hospital, Parkland Hospital, and Children's Medical Center, Dallas, TX; Stanley Prusiner, MD, Director, Institute for Neurodegenerative Diseases;Professor of Neurology and Biochemistry, University of California, San Francisco, School of Medicine; Salvatore DiMauro, MD,Lucy G. Moses Professor of Neurology, Columbia University College of Physicians and Surgeons, New York; Robert L Barchi, MD PhD, Provost;Professor of Neurology and Neuroscience University of Pennsylvania School of Medicine, Philadelphia; and Eric J. Nestler, MD PhD, Lou and Ellen McGinley Professor and Chairman; Department of PsychiatryThe University of Texas Southwestern Medical Center