Wilson and Gisvold's Textbook of Organic Medicinal and Pharmaceutical Chemistry

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For over half a century, Wilson and Gisvold's Textbook of Organic Medicinal and Pharmaceutical Chemistry has served the discipline of medicinal chemistry for both graduate and undergraduate pharmacy and chemistry students as well as practicing pharmacists. Fully updated for the Twelfth Edition, the book begins with the fundamental principles of chemistry, biochemistry, and biology that underlie the discipline of medicinal chemistry. These principles are then applied to understanding the properties, mode of action, therapeutic applications, and limitations of various pharmaceutical agents. The subject matter is organized by pharmaceutical and therapeutic classes, providing a bridge between the basic sciences and clinical practice. The text contains many tables for quick reference to names, formulations, dosages, and applications. This edition includes chapter review questions and cases. A companion website provides online updates of medicinal chemistry structures and an image bank for faculty.

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John M Beale Jr., PhD, AssociateProfessor of Medicinal Chemistry, Division of Basic and Pharmaceutical Sciences, St. Louis College of Pharmacy, St. Louis, MO Table of Contents 1. Introduction 2. Drug Design Strategies 3. Metabolic Changes of Drugs and Related Organic Compounds 4. Biotechnology and Drug Discovery 5. Immunobiologicals 6. Anti-infective 7. Antimalarials 8. Antibacterial Antibiotics 9. Antiviral Agents 10. Antineoplastic Agents 11. Agents for Diagnostic Imaging 12. Central Nervous System Depressant 13. Central Dopaminergic Signaling Agents 14. Anticonvulsants 15. Central Nervous System Stimulants 16. Adrenergic Agents 17. Cholinergic Drugs 18. Renal Acting Agents 19. Cardiovascular Agents 20. Hormone Related Disorders: Nonsteroidal Therapies 21. Agents Treating Bone Disorders 22. Anesthetics 23. Histamine and Antihistaminic Agents 24. Analgesics 25. Steroids and Therapeutically Related Compounds 26. Prostaglandins, Leukotrienes, and Other Eicosanoids 27. Proteins, Enzymes and Peptide Hormones 28. Vitamins and Related Compounds 29. An Introduction to the Medicinal Chemistry of Herbs Appendix, Calculated Log 0, Log D and pKa