Biology of the NMDA Receptor

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Explores the role of NMDARs in brain development from a circuit perspective, on the single neuron level, and on the synaptic level Examines the role NMDARs play in the pathology of Huntington???s Disease Describes the mechanisms underlying DA???NMDA receptor interactions, particularly in the striatum Provides an overview of NMDAR regulation by serine/threonine and tyrosine phosphorylation, and the cross-talk between these kinase/phosphatase signaling pathways Covers the physiological roles NMDARs play in the mammalian nervous system and the molecular and structural bases of NMDAR activation The NMDA receptor plays a critical role in the development of the central nervous system and in adult neuroplasticity, learning, and memory. Therefore, it is not surprising that this receptor has been widely studied. However, despite the importance of rhythms for the sustenance of life, this aspect of NMDAR function remains poorly studied. Written by one of the world???s leading authorities on NMDA receptors, Biology of the NMDA Receptor brings together virtually all the players in this important field. Contents of the book : NMDA Receptors and Brain Development,NMDA Receptors and Huntington???s Disease, NMDA and Dopamine Diverse Mechanisms Applied to Interacting Receptor Systems, NMDA Receptors and Alcohol Addiction, Transcriptional Regulation of NMDAR Expression, NMDARs and Translational Control, Regulation of NMDARs by Kinases and Phosphatases,Trafficking and Targeting of NMDARs, NMDAR-Mediated Calcium Transients in Dendritic Spines, NMDA Receptors in Drosophila, Extracellular Modulation of NMDARs, Pharmacology of NMDARs, Activation Mechanisms of NMDARs, Presynaptic NMDARs