Infection And Immunity

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Infection and Immunity describes the main causes of infection that our bodies have to battle against - from bacteria to viruses, fungi to protozoa - and explains the intricate and fascinating ways that our bodies respond to infection - from detection of these potentially dangerous organisms, to their ultimate elimination. Our immune system is a complex network of cells continually working against a barrage of attack from our environment to, quite literally, save our lives. But how do our bodies protect us from the bacteria, and other potentially life-threatening organisms, that surround us every day?Infection and Immunity , third edition, explains how, in the lucid, accessible style for which John Playfair is renowned. With examples of infectious diseases from across the world, this book is perfect for biomedical science, bioscience and microbiology students who need to understand what causes infection, and how our immune system respond. Key Features A careful integration of two disciplines striking a clear and thoughtful balance between immunology and microbiology. Includes examples of infectious disease from around the world Tutorials and reading lists provided at the end of each section to support student and clarify concepts covered Increased coverage on disease control including epidemiology Extended clinical correlations: additional explanations demonstrate the clinical relevance of the topics being covered. Accompanied by Online Resource Centre

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John Playfair Formerly Chairman, Department of Immunology, University College London Medical School Gregory Bancroft The London School of Hygiene and Tropical Medicine Table of Contents 1. The infectious organisms 1. Introduction: parasites, pathogens, and immunity 2. Viruses 3. Bacteria 4. Fungi 5. Protozoa 6. Helminths (worms) 7. Prions 8. Disease: virulence and susceptibility 2. The immune system 9. Defence, immunity, the immune system 10. External defences: entry and exit 11. Innate immunity 12. How pathogens escape innate immunity 13. Disease due to innate immunity 14. Immunodeficiency I: primary defects of innate immunity 15. Adaptive immunity: introduction 16. B cells and antibody 17. T cells and the MHC 18. The antibody response 19. Cell-mediated responses 20. Regulation of immune responses and memory 21. How pathogens escape adaptive immunity 22. Disease due to adaptive immunity I: hypersensitivity 23. Disease due to adpative immunity II: autoimmunity 24. Immunodeficiency II: primary defects of adpative immunity 25. Immunodeficiency III: secondary immunodeficiency and AIDS 3. The host-pathogen balance 26. Epidemiology 27. Control of infectious disease: vaccination 28. Control of infectious disease: chemotherapy 29. Control of infectious disease: public health measures 30. Viral and prion disease and immunity 31. Bacterial disease and immunity 32. Fungal disease and immunity 33. Protozoal disease and immunity 34. Helminth disease and immunity 35. Emerging and future infectious diseases Glossary Appendices Further Reading and Information Hints and Suggestions for Answers to Tutorial Questions Index